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Champions League predictions - 30 September 2025, Round 2

Simon Lewis
Editor
Last updated: 29 Sep 2025

This article offers predictions for four key Champions League fixtures: Chelsea is tipped to edge Benfica in a low-scoring match despite missing Cole Palmer, with under 2.5 goals the best bet. Atlético Madrid is favored to win to nil against Frankfurt, exploiting their home advantage and defensive solidity. Liverpool faces a resilient Galatasaray, but their strong form suggests a narrow win or draw, with both teams likely to score. Real Madrid's firepower should see them overcome Kairat Almaty by at least two goals after controlling the game, especially in transition.

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Simon Lewis 29 Sep 2025
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  • Chelsea to pip Benfica in tough battle.
  • In-form Atlético Madrid to blow Frankfurt away.
  • Galatasaray to test guests Liverpool to the end.
  • Real Madrid to mow down Kairat Almaty.
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Kylian Mbappe
Kylian Mbappe has scored 12 goals in 10 matches. (credit: Angel Martinez/Getty Images)

Champions League Predictions


Chelsea vs Benfica


Chelsea have lost three of their last four matches, including their Champions League opener against Bayern Munich. The loss of Cole Palmer for a couple of weeks is a big blow, especially in Europe. Benfica travel well in Europe and are quick on the counter, but their set-piece defending has wobbled. My call is that Chelsea will use their home ground advantage and cautious tactics to pull off a win in a low-chance game. 
Prediction: Chelsea by one.
Best bet: Under 2.5 goals.
Result odds: Chelsea 1.62 | Draw 4.00 | Benfica 4.75.

Atlético Madrid vs Frankfurt


Atlético’s press-and-punish blueprint under Simeone usually translates at home, with them winning their last three home matches including a 5-2 thumping of Real Madrid. Julian Alvarez and Antoine Griezmann should torment a Frankfurt side that can be careless playing out. The Germans carry the punch on transitions but may struggle for territory. 
Prediction: Atlético to win to nil.
Best bet: Atlético -0.5 handicap.
Odds range: Atlético 1.55 | Draw 4.33 | Frankfurt 5.00.

Galatasaray vs Liverpool


Liverpool have won 13 of their last 14 games in Champions League group matches and are in great form in the EPL, although they lost their first match of the season against Crystal Palace on the weekend. Virgil van Dijk should be key for Liverpool all over the park. Gala have lost 12 of their last 18 Champions League matches and haven’t lost at home since 2018. They will be hoping German general Gundogan can work some magic, as he did against Frankfurt, where he set up four chances on his UCL debut for Gala.
Prediction: Draw or Liverpool by one.
Best bet: Both teams to score.
Odds range: Galatasaray 4.33 | Draw 4.33 | Liverpool 1.62.

Kairat Almaty vs Real Madrid


A long trip to Kazakhstan plus unfamiliar altitude and surface could slow Madrid early, but their individual quality in transition should create boundless moments for Mbappé to bury the ball. The Madrid goal machine has scored 12 goals in his last 10 matches, netting in all but one of those matches. Expect patient control, then late separation from Almaty, who are dogged in defence and could frustrate Madrid, but once the floodgates open they will have little resistance to offer. 
Prediction: Real Madrid by three.
Best bet: Real Madrid to win & under 4.5 goals (bet builder).
Odds range: Kairat 10.0–15.0 | Draw 5.00–6.50 | Real Madrid 1.28–1.45.

Verdict

Big wins for Real Madrid and in-form Atlético Madrid.

Tough battles in store for Galatasaray/Liverpool and Chelsea/Benfica.
      
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