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Serie A predictions - 27 September 2025, Matchday 5

Simon Lewis
Editor
Last updated: 26 Sep 2025

This article analyzes three major Serie A fixtures, offering key predictions and tactical insights. Como is tipped to leverage their home advantage narrowly against Cremonese. Juventus and Atalanta are set for a thrilling face-off, with both teams likely to score, but Juventus expected to secure the win. Meanwhile, Inter’s attacking prowess is likely to see them win away at Cagliari. Predictions include Como to win, both teams to score in Juventus vs Atalanta, and Inter to win with over 1.5 goals.

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Simon Lewis 26 Sep 2025
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  • Como-Cremonese clash to result in tight win for Como.
  • Lots of goals as Juve host Atalanta.
  • No trouble scoring away from home for Inter against Cagliari.
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Juventus
Juventus' Dusan Vlahovic battles against Hellas Verona. (credit: Photo Agency/Getty Images)

Serie A Predictions


Como vs Cremonese 

Como’s home crowd at Sinigaglia definitely add a player to Como's playing XI. Expect measured build-up and crosses from Como. Cremonese are tidy but can be pushed back, so this will be a game of tight margins, with Como to shade it.

Juventus vs Atalanta

Juventus’ control game against Atalanta’s high-octane press should be fascinating. Transitional moments for Juve’s forwards could decide it if they bypass the press. I see this as a game in which both teams are likely to score, and I am leaning towards Juve to take maximum points.

Cagliari vs Inter 

Inter’s patterns and wing-back supply usually travel well, and although Cagliari will be up for a scrap, they have a tendency to concede territory. If Inter convert early then this match will settle quickly. I’m backing Inter to take the match points by one or two goals.

Verdict

Como set for tough fight to beat Cremonese at home.

Juventus and Atalanta set for big-scoring clash, while Inter should play out a trouble-free win away from home.
     
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Simon Lewis

Sports Editor • 20+ years betting experience

Simon is a talented sports writer in South Africa with a strong focus on cricket having played first-team level for UCT, including playing at two Universities Weeks.


From a young age Simon was an avid reader of cricket magazines and books, and went on to be Editor of The Googly, CricketScene SA and SA Cricket, in addition to being a Features Writer on SA Sports Illustrated. 

He has interviewed most of South Africa's premier cricketers and was the first writer to interview a teenaged Jacques Kallis.

Simon has also written about English and local football, rugby and cricket, in addition to major international tennis and golf stars and competitions.

You can follow more from Simon at Muckrack, X and LinkedIn.

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Italian Serie A

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